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Question: Quiescent satellite cells are a mix of satellite stem cells (~10%) and committed satellite cells (~90%). Describe the steps by which committed satellite cells enable the generation of myocytes and regeneration of myofibres following activation.
1. Following activation, committed satellite cells undergo a process called myogenic differentiation to become myoblasts. 2. Myoblasts go through a process of mitosis and divide, generating more myoblasts. 3. Myoblasts nearby fuse together to form nascent myofibres. 4. With continued mitosis and fusion, the myofibres gain size and complexity. 5. As the myofibres mature, they become myocytes and the nuclei begin to develop distinct regions. 6. With the development of the nuclei, the myocytes become physiologically functional and the myofibres can regenerate.
Jan. 16, 2023, 2:04 a.m.
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