There are several software options for making interactive 3D mechanical simulations. Some popular choices include SolidWorks, Siemens NX, ANSYS, and COMSOL Multiphysics. Each of these software packages has its own strengths and weaknesses depending on the specific requirements of the simulation, so it is important to evaluate each one before making a final decision. Additionally, it may be helpful to look for software specifically designed for the type of simulation you need, such as finite element analysis (FEA) or computational fluid dynamics (CFD) simulations.