When replying to a question about your biggest pet peeve, you should first consider which personal annoyance bothers you the most. Be honest, yet respectful in your response. You can reply with something like: "One of my biggest pet peeves is when people constantly interrupt others during conversations. I believe that listening is crucial in any discussion, and it can be frustrating when someone continuously cuts off someone else before they have a chance to finish their point. I think it's important to be patient and allow others to express their opinions before responding."