When replying to someone who says they have never been in a relationship, it's important to be understanding and empathetic. Here's an appropriate response: "I totally understand that everyone's journey and experience with relationships are different. It's completely okay to have never been in a relationship. The right person will come into your life when the time is right. Just focus on self-improvement and building strong friendships. Remember, it's better to be single than to be with the wrong person."